Nootropics overview
A growing family of neuro-active research peptides, from the Russian nootropics Semax and Selank through Noopept, Dihexa, Cerebrolysin, DSIP and more, studied for cognition, stress resilience, mood and sleep. This section covers what the class is, what the literature looks at, and how each compound sits in our catalogue.
Several of the compounds gathered here are sometimes called the “Russian nootropic peptides”: short, synthetic sequences derived from naturally occurring fragments and studied in research models for effects on memory, focus, anxiety and sleep regulation. Others, such as Dihexa, PE-22-28 and Cerebrolysin, come from different research lineages but share the same broad focus on the central nervous system. Everything documented here is supplied strictly for laboratory research use only, not for human or veterinary use.
What nootropic peptides are
Nootropic peptides are short amino-acid sequences investigated for their influence on the central nervous system, the pathways behind cognition, focus, stress resilience and related neuro signalling. Unlike the metabolic or repair peptides covered elsewhere in these docs, this class is studied primarily for its effects on the brain: neurotrophic signalling (such as BDNF), neurotransmitter modulation and the regulation of sleep and the stress response.
Cognition & focus
Sequences studied in research models for memory, attention and learning-related pathways.
Stress & mood
Interest in anxiolytic and stress-response effects without classical sedation in the literature.
Sleep & rhythm
Neuropeptides investigated for sleep regulation and circadian-rhythm modulation.
The compounds
This section spans ten compounds across three research themes. Each has its own page with a detailed mechanism, sourced study data, class, molecular weight and CAS.
Cognition & focus
Semax
A synthetic heptapeptide based on ACTH(4-10), researched for nootropic and neuroprotective effects and BDNF upregulation.
Read about SemaxN-Acetyl Semax Amidate
An acetylated, amidated Semax variant engineered for greater metabolic stability.
Read about itNoopept
A proline-containing dipeptide studied for NGF and BDNF expression and HIF-1 activation.
Read about NoopeptDihexa
An angiotensin IV-derived peptide studied for HGF/c-Met signalling and synaptogenesis.
Read about DihexaP21 (P021)
A CNTF-derived tetrapeptide studied for neurogenesis and BDNF in preclinical models.
Read about P21Mood & anxiety
Selank
A synthetic tuftsin-analogue heptapeptide studied for anxiolytic and cognitive effects, a sibling of Semax.
Read about SelankN-Acetyl Selank Amidate
A stabilised acetylated, amidated Selank variant studied alongside the parent peptide.
Read about itPE-22-28
A spadin-derived TREK-1 blocker investigated as a fast-acting antidepressant candidate.
Read about PE-22-28Sleep & neuro-repair
DSIP
Delta Sleep-Inducing Peptide, a neuropeptide investigated for sleep regulation, stress response and circadian rhythm.
Read about DSIPCerebrolysin
A brain-derived peptide preparation studied in stroke, dementia and traumatic brain injury research.
Read about CerebrolysinRelated science
For the mechanism background behind these and the other compound families, and for a searchable index of molecular weights, CAS numbers and classes, see the science and reference sections.